Hypothesis

                    It is the tension  between creativity and skepticism that has produced the stunning and unexpected findings of science.     —Carl Sagan 

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If spectinomycin at concentration of one deviation below its MIC is applied to E. coli with an application of ultrasound, then ultrasound will enhance the inhibition of E. coli to produce a synergistic effect. Drawing on previous research, ultrasound is known to enhance the transport of small molecules across polymer membranes and gels. If similar transporting enhancement occurs in this case, then increased transport of spectinomycin into the cell may be responsible for the increasedinhibition/killing of bacteria.  

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Enhancement of Antibiotic Action with an Application of Ultrasound
by Liz Meng: lizmeng10@hotmail.com
Victor Feng: haovictor_feng@hotmail.com
Sir Winston Churchill High School, Calgary.AB

01/05/2007