It
is the
tension 
between creativity and skepticism that has produced the stunning
and unexpected
findings of science. —Carl Sagan
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Ultrasound has been found to enhance the transport of
certain small molecules across porous membranes, and some large molecules such
as DNA through agarose [i]
and insulin through skin [ii],
although the exact mechanisms of action are not known. The enhancement has been
speculated to be due to the “increased microconvection from ultrasonic heating
and ultrasonic cavitation” [iii],
thus inducing an increase rate of permeation of oxygen through the biofilm will
activate the previously dormant bacteria, so that the antibiotic is able to make
an attack on the bacteria’s structures. Other
research has also shown that ultrasound enhances the transportation of
gentamicin across colony biofilms of Pseudomonoa
aeruginosa and Escherichia coli[iv].
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Enhancement of Antibiotic Action with an Application of
Ultrasound 29/04/2007 |
