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Introduction

Nordihydroguaiaretic Acid (NDGA) is a chemical found naturally in the Creosote bush of Mexico.

Picture #1: CHEMICAL STRUCTURE OF NDGA


(Dr. Alcorn)

     The extract from the Creosote bush, NDGA, is used by people to relieve themselves of many ailments including gall stones, kidney stones, and urinary tract infections. Some people even use it as a treatment for diabetes, it is also a known antioxident. The positive effects of NDGA on the body include its use as an anti-inflammatory because it mitigates the inflammatory response in the skin. NDGA can also reduce the effect of Ultra Violet radiation on the skin cells. Is also prevents the build up of fat deposits on the skin and can actually inhibit the production of enzymes that can break down the skin.
     NDGA is a complementary/alternative medicine (CAM) and because of this few clinical studies on NDGA have been done. The low number of trials has made it so that there is a lack of knowledge surrounding this chemical. One of the more reputable sources shows that large amounts consumed or consumption over a long period of time may result in hepatotoxicity. There is still controversy surrounding whether the hepatotoxicity is a direct result of the NDGA.

.: (C) Mithum Kularatne and Andrew Plishka - Canada Wide Virtual Science Fair 2007 :.