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Project Information
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Names: Mithum Kularatne and Andrew Plishka
Group Category: 10-12
Team Size: 2
Subject Area: Health/Sport
Project Type: Experimental
Language: English
Summary:
Nordihydroguaiaretic Acid (NDGA) is a chemical naturally found in the creosote bush of Mexico and is used traditionally as a reliever of many ailments such as gall stones and kidney stones. Recently NDGA has become more commercialized even though that the knowledge surrounding it is somewhat ambiguous.
The purpose of this experiment is to clear up some of the ambiguity surrounding NDGA and it’s effects. It was found that NDGA was toxic to the liver cells because a far greater number of cells were dead than the control group.
Two potential mechanisms that could cause the toxicity in liver cells were identified.
It is intended that further research be done allowing safe commercialization of NDGA as a pharmaceutical drug for various ailments.
Software Tools Used: Macromedia Dreamweaver MX, Notepad++, Adobe Photoshop CS2, Microsoft Word, Filezilla
Hardware Tools Used: Computer, See Materials for full list of tools used in the experimentation process.
Source of the Idea: We were very interested in doing a project about the different aspects of pharmaceuticals and through our research we came across the chemical Nordihydroguaiaretic Acid (NDGA). We became interested because of the ambiguity surrounding NDGA in regards to it's cytotoxicity and decided to pursue it.
Special Skills Used: HTML, CSS, Graphics Design
Awards: This project won third place at the Saskatoon Regional Science Fair in the category of Health Science.
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