Alkyl benzene sulfonates or ABS: A class of synthetic surfactants (usually identified as “anionic surfactants.”) ABS is very slow to biodegrade and seldom used. LAS, however, are the most common surfactants in use. During the manufacturing process, carcinogens and reproductive toxins such as benzene are released into the environment. While LAS do biodegrade, they do so slowly. The pure compounds may cause skin irritation on prolonged contact.

Alkyl phenoxy polyethoxy ethanols: This is a general name for a group of synthetic surfactants. They are slow to biodegrade in the environment and have been implicated in chronic health problems. Researchers in England have found that in trace amounts they activate estrogen receptors in cells, which in turn alters the activity of certain genes. For example, in experiments they have been found to stimulate the growth of breast cancer cells and feminize male fish. One member of this family of chemicals is used as a common spermicide, indicating the general level of high biological toxicity associated with these compounds.

Artificial fragrances: Artificial fragrances are made from petroleum. Many do not degrade in the environment, and may have toxic effects on both fish and mammals. Additionally, they often can cause allergies and skin or eye irritation.

Optical brighteners: are a broad classification of many different synthetic chemicals that, when applied to clothing, convert UV light wavelengths to visible light, thus making laundered clothes appear "whiter." Their inclusion in any formula does not enhance or affect the product's performance in any way; they simply trick the eye. Optical brighteners do not readily biodegrade. They are toxic to fish when washed into the general environment and can create bacterial mutations. They can cause allergic reaction when in contact with skin that is then exposed to sunlight.

Phosphates: a key nutrient in ecosystems, phosphates are natural minerals important to the maintenance of all life. Their role in laundry detergents is to remove hard water minerals and thus increase the effectiveness of the detergents themselves. They are also a deflocculating agent; that is, they prevent dirt from settling back onto clothes during washing. While relatively non-irritating and non-toxic in the environment, they nonetheless contribute to significant eutrophication of waterways and create unbalanced ecosystems by fostering dangerously explosive marine plant such as algae and can cause algae blooms.

Polyethylene glycol (also PEG): Another type of anti-redeposition agent, PEG is a polymer made from ethylene oxide and is similar to some non-ionic detergents. Not considered toxic, it takes large doses to be lethal in animals. However, PEG is slow to degrade and is synthetic.

Quaternium 15: An alkyl ammonium chloride used as a surfactant, disinfectant and deodorant that releases formaldehyde, a potent toxin.